How do tissue scaffolds work?
A tissue scaffold provides a 3D framework which cells can invade into, and blood capillaries also form with this lattice, functioning to bring it to life, and bring the immune system to protect the new tissue territory.
In healing by ‘secondary intention’ scar-forming cells build up on the wound bed, resulting in scar tissue formation. In contrast, a tissue scaffold can accelerate tissue regrowth. It gives a framework for cells and blood capillaries to migrate into, and subsequently organise into a normal dermis.
The essential clinical properties of a scaffold is biological efficacy to support cellular ingrowth, immediate wound cover, rapid integration, accelerated healing and non-scarring outcome.
Additionally, the product should be:
Robust and handleable
‘Off-the-shelf’
Cost-effective
(Van der Veen, 2011).
What is the difference between types of scaffold?
The particular properties of each scaffold are determined by the physical properties such as the microscopic structure, the mechanical properties, as well as the chemical or biochemical composition and properties. All of these contribute to the overall properties and actual extent of clinical usefulness.
References
van der Veen, V. C., B. K. Boekema, M. M. Ulrich and E. Middelkoop (2011). "New dermal substitutes." Wound Repair Regen 19 Suppl 1: s59-65.